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  TGex-遗传病解读整体方案

TGex是美国LifeMap公司基于GeneCards知识库开发的遗传病解读整体方案。利用超过160个数据源(详见附录)提供证据支持,数据每月更新,保障信息时效性;独特的VarElect表型工具支持中英双语输入,并将基因按照与表型关联性进行评分排序,研究人员可以从TGex界面中迅速探索人类基因、基因变异、蛋白质、细胞、生物学途径、疾病、药物和相互之间的关系;此外TGex可以根据基因和表型之间关联、提供支持证据,自动产生案例报告,让NGS分析更加强大。

 

TGex workflow
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附录:
TGex数据源一览表(持续更新中)
1. Addgene The non profit plasmid repository: Addgene provides a non-profit plasmid repository, and is dedicated to helping scientists around the world share high-quality plasmids
2. Abcam: Abcam: maker and commercial supplier of primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits
3. AceView: AceView offers an integrated view of the human and nematode genes as reconstructed by mRNA and EST alignments
4. antibodies-online: antibodies-online, a marketplace for research reagents, offers >1 million research antibodies, ELISA kits, proteins and related products from over 150 suppliers
5. ApexBio - An Apoptosis and Epigenetics Company: ApexBio provides peptides and lab reagents for biological research
6. Atlas: ATLAS of Genetics and Cytogenetics in Oncology and Haematology
7. BioGPS: BioGPS is a service from the Genomics Institute of Novartis Research Foundation which provides an integrated portal which displays gene-centric annotation, including "annotation" based on reference gene expression data sets
8. BitterDB: BitterDB provides several ways to investigate the bitter world: search for bitter compounds by different criteria, search for bitter molecules with structure similar to a query compound, blast bitter receptors and more.
9. Blocks: BLOCKS is a database of Blocks multiply aligned ungapped segments corresponding to the most highly conserved regions of proteins
10. Blood Group Antigen Gene Mutation Database: BGMUT is the Blood Group Antigen Gene Mutation Database of variations in the genes that encode antigens of blood group systems
11. BRCA Exchange: The BRCA Exchange aims to advance our understanding of the genetic basis of breast cancer, ovarian cancer and other diseases by pooling data on BRCA1/2 genetic variants and corresponding clinical data from around the world.
12. Cell Signaling Technology: CST (Cell Signaling Technology) provides discovery tools for cell signaling research, including information about pathways and phosphorylation sites
13. Centers for Disease Control and Prevention: The Centers for Disease Control and Prevention (CDC) contains information about various diseases and health conditions.
14. CGAP SAGE: CGAP (The Cancer Genome Anatomy Project) determines the gene expression profiles of normal, precancer, and cancer cells,leading eventually to improved detection, diagnosis, and treatment for the patient
15. Clinical Interpretation of Variants in Cancer: CIViC is an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer. Their goal is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations.
16. ClinicalTrials.gov: ClinicalTrials.gov is a registry and results database of federally and privately supported clinical trials conducted in the United States and around the world.
17. ClinVar: ClinVar archives and aggregates information about relationships among variation and human health
18. Cloud-Clone Corp.: Cloud-Clone Corp.: produces ELISA Kits and other relevant life sciences reagents covering a full range of fields.
19. COMPARTMENTS Subcellular localization database: COMPARTMENTS Subcellular localization database integrates evidence on protein subcellular localization from manually curated literature, high-throughput screens, automatic text mining, and sequence-based prediction methods
20. Cyagen Biosciences Inc.: Cyagen Biosciences Inc. is a contract research organization and cell culture product manufacturer, a leader in custom animal models and molecular biology tools.
21. Data Mining of Enzymes: Data Mining of Enzymes (DME): a Web service that provides Specific Peptides for arbitrary proteins, determining from its sequence whether a protein is an enzyme and what the enzyme's EC classification is
22. Database of Genetic Variants: The Database of Genomic Variants (DGV) provides a comprehensive summary of structural variation in the human genome
23. dbSUPER: dbSUPER is the first integrated and interactive database of super-enhancers in human and mouse, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease.
24. Disease Ontology: Disease Ontology provides a hierarchical open source ontology for the integration of biomedical data that is associated with human disease.
25. diseasecard: Diseasecard is an information retrieval tool for accessing and integrating genetic and medical information for health applications.
26. DrugBank: The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information
27. eBioscience: eBioscience, an Affymetrix company, leads in immunology and oncology flow cytometry reagents, and offers large selections of antibodies, ELISAs and proteins for Life Science research and diagnostics
28. EMD MILLIPORE: EMD Millipore offers a broad range of Life Science tools, technologies, and services, and creates personalized solutions to industry challenges to assure scientific success
29. ENCODE: The ENCODE (Encyclopedia of DNA Elements) Consortium is an international collaboration of research groups with the goal to build a comprehensive list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.
30. Ensembl: Ensembl: a software system producing and maintaining automatic annotation on eukaryotic genomes, which provides identification of known human genes in the genome sequence, prediction of additional genes with supporting evidence, and ortholog predictions based on duplication aware phylogenetic trees
31. Ensembl Pan Taxonomic Compara: Ensembl pan taxonomic compara: A broad view of homologous relationships across representative genomes from all significant clades represented in Ensembl and EnsemblGenomes
32. Enzo Life Sciences: Enzo Life Sciences incorporates BIOMOL, a supplier of specialty biochemicals, with applications in signal transduction, lipid research, apoptosis,neuroscience and drug discovery
33. ESI BIO: ESI BIO provides human embryonic stemcell lines and human embryonic progenitor cells
34. euGenes: euGenes: Genomic Information for Eukaryotic Organisms Database for more details on similar genes in other organisms
35. FANTOM5 Human Transcribed Enhancer Atlas: A database describing enhancer regions defined by CAGE tags in the FANTOM5 project.
36. FlyBase: a database of the Drosophila genome.
37. fRNAdb: A comprehensive non-coding RNA sequence database
38. GENATLAS: Genatlas: a catalog of genes, markers and phenotypes with many links to major data sources. GeneCards offers the short description of the gene that often contains interesting, concise information about its cellular functions and/or role in diseases
39. GenBank: the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences.
40. Gene Ontology: GO, the Gene Ontology, is a dynamic controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing
41. Gene ORGANizer: Gene ORGANizer is a tool designed to allow users to analyze the relationships between genes and organs. It contains annotations for over 7,000 genes, which are linked to ~150 body parts.
42. Gene Wiki: Gene Wiki is a project that facilitates transferring information on human genes to Wikipedia article stubs with the goal of promoting collaboration and expansion of the articles
43. GeneAnnot: Annotation of high-density oligunocleotide arrays at the Weizmann Institute of Science, with links to Affymetrix probe-sets.
44. GeneCards: GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes
45. GeneGo (Thomson Reuters Life Sciences Research): GeneGo (Thomson Reuters) Maps are interactive pathways with consensus knowledge on signaling and metabolism involved in human biology and diseases
46. GeneLoc: GeneLoc (formerly The Unified DataBase (UDB)) integrates information on the human genome, with emphasis on mapping information. Mapped DNA segments, classified by categories (such as genes, EST clusters and STSs mapped by various methods) are presented on a Megabase-scale integrated map, with further links to relevant databases
47. GeneReviews: GeneReviews are expert-authored, peer-reviewed disease descriptions presented in a standardized format and focused on clinically relevant and medically actionable information on the diagnosis, management, and genetic counseling of patients and families with specific inherited conditions.
48. GENETests: GeneTests (formerly GeneClinics): a clinical information resource relating genetic testing to the diagnosis, management, and genetic counseling of individuals and families with specific inherited disorders
49. GeneTex: GeneTex provides GeneCards with antibodies and recombinant proteins, and strives to serve and accelerate life science research by creating essential biomedical reagents where quality can be found in every vial
50. Genetic Association Database: The Genetic Association Database (GAD) is an archive of human genetic association studies of complex diseases and disorders
51. Genetic Testing Registry: The Genetic Testing Registry (GTR) provides a central location for voluntary submission of genetic test information by providers. The scope includes the test's purpose, methodology, validity, evidence of the test's usefulness, and laboratory contacts and credentials.
52. Genetics Home Reference: Genetics Home Reference provides consumer-friendly information about the effects of genetic variations on human health.
53. Genome Annotation for Alternative Splicing: A new EST clustering method that produces gene models based on genomic alignment of mRNA and ESTs
54. GenomeRNAi: Genome RNAi is a database containing phenotypes from RNA interference (RNAi) screens in Drosophila and Homo sapiens. In addition, the database provides an updated resource of RNAi reagents and their predicted quality
55. GenScript: GenScript is a biology clinical research organization focusing exclusively on early drug discovery and development services
56. HomoloGene: HomoloGene: a resource of curated and calculated orthologs for genes as represented by UniGene or by annotation of genomic sequences
57. HORDE: HORDE is the Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science
58. Horizon: Horizon is a fully integrated life science company that provides enabling products, services and research programs to clients engaged at every stage of the healthcare continuum from sequence to treatment.
59. HUGE: HUGE: the Database of Human Unidentified Gene-Encoded Large Proteins
60. Hugo Gene Nomenclature Committee: HUGO Gene Nomenclature Committee (HGNC) is the central clearinghouse for assigning gene names
61. Human Cytochrome P450 Allele Nomenclature Database: The Human Cytochrome P450 Allele Nomenclature Database is a database of CYP alleles and their associated effects
62. Human Gene Damage Index: The gene damage index (GDI) is the accumulated mutational damage of each human gene in healthy human population, based on the 1000 Genomes Project database (Phase 3) gene variations of healthy individuals and of the CADD score for calculating impact.
63. Human Gene Mutation Database: HGMD (Human Gene Mutation Database): information about disease-causing mutations in genes. GeneCards presents a link to specific entries in this database whenever they can be found
64. Human Genome Epidemiology Navigator: The HUman Genome Epidemiology Navigator: An integrated, searchable knowledge base of genetic associations and human genome epidemiology
65. Human Metabolome Database: HMDB (The Human Metabolome Database) is an electronic database containing detailed information about small molecule metabolites found in the human body
66. Human-Invitational Database: HInv-DB: H-Invitational Database (H-InvDB) is an integrated database of curated annotations of human genes and transcripts
67. Hypergeometric Optimization of Motif Enrichment: Hypergeometric Optimization of Motif EnRichment is a suite of tools for Motif Discovery and next-gen sequencing analysis
68. Illumina Human BodyMap: Illumina Human BodyMap: RNA obtained from 16 normal human tissues was sequenced and mapped to genes via their transcripts
69. ImMunoGeneTics Information System: ImMunoGeneTics Information System (IMGT): a high-quality integrated information system specialising in Immunoglobulins (IG), T cell receptors (TR) and Major Histocompatibility Complex (MHC) molecules of all vertebrate species
70. IntAct: IntAct: IntAct provides a freely available, open source database system and analysis tools for protein interaction data. All interactions are derived from literature curation or direct user submissions and are freely available
71. Integrated Interactions Database: IID (Integrated Interaction Database) is an on-line database of known and predicted eukaryotic protein-protein interactions, in 30 tissues of model organisms and humans.
72. International Union of Basic and Clinical Pharmacology: The IUPHAR: Guide to Pharmocology provides a searchable database with quantitative information on drug targets and the prescription medicines and experimental drugs that act on them
73. International Union of Biochemistry and Molecular Biology: IUBMB: The International Union of Biochemistry and Molecular Biology - the Nomenclature Committee
74. InterPro: InterPro: a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to unknown protein sequences
75. Invitrogen by Thermo Fisher Scientific: Thermo Fisher Scientific provides analytical instruments, laboratory equipment, software, services, consumables and reagents
76. KEGG, Kyoto Encyclopedia of Genes and Genomes: Kyoto Encyclopedia of Genes and Genomes (KEGG) provides pathway information
77. Leiden Muscular Dystrophy: Leiden Muscular Dystrophy pages are specifically designed for scientists performing research and/or diagnosis in Duchenne and Duchenne-like muscular dystrophies
78. LifeMap Sciences: LifeMap: a web based discovery platform aiding research and product development efforts in the stem cells field
79. Locus Specific Mutation Databases: LSDB: The Human Genome Variation Society's Locus Specific Mutation Databases
80. MalaCards: MalaCards: an integrated database of human maladies and their annotations, modeled on the architecture and richness of GeneCards, and leveraging GeneDecks and GeneNote
81. Medical Subject Headings: MeSH is the National Library of Medicine's controlled vocabulary thesaurus. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity.
82. MedlinePlus: Medlineplus contains health information from the National Library of Medicine.
83. miRBase: miRBase is the new home for microRNA data, incorporating the database and gene naming roles previously provided by the miRNA Registry, and including the new miRBase Target database
84. miRTarBase : miRTarBase is a database that curates experimentally validated microRNA-target interactions
85. Molecular INTeraction database: MINT (Molecular Interactions Database) focuses on experimentally verified protein interactions with special emphasis on proteomes from mammalian organisms, consists of entries mined in the scientific literature by curators
86. MOPED: Model Organism Protein Expression Database (frozen)
87. Mouse Genome Informatics: MGI (Mouse Genome Informatics, formerly MGD) provides a comprehensive source of information on the experimental genetics of the laboratory mouse; it includes information on mouse markers, mammalian homologies, probes and clones. GeneCards presents links to mammalian homology pages, the name of the mouse gene, its location (in centiMorgan), phenotypic alleles, and links to the entries for the mouse gene
88. National Institute of Neurological Disorders and Stroke: The National Institute of Neurological Disorders and Stroke (NINDS) conducts and supports research on brain and nervous system disorders.
89. NCBI: National Center for Biotechnology Information creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information
90. NCBI BioSystems Database: The NCBI BioSystems Database provides integrated access to biological systems and their component genes, proteins, and small molecules, as well as literature describing those biosystems and other related data throughout Entrez
91. NCBI Bookshelf: The NCBI Bookshelf provides free online access to books and documents in life science and healthcare.
92. NCBI Entrez Gene: EntrezGene at NCBI provides a single query interface to curated sequence and descriptive information about genetic loci
93. NCBI Reference Sequence Database: RefSeq: NCBI Reference Sequence Database A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
94. NCBI-PubMed: PubMed: NLM's search service to access the 9 million citations in MEDLINE and Pre-MEDLINE (with links to participating on-line journals), and other related databases
95. NEXTPROT: neXtProt offers seamless integration of human protein data
96. NIH Rare Diseases: The Office of Rare Diseases Research (ORDR) at the National Institutes of Health (NIH) coordinates research and information on rare diseases.
97. NONCODE: NONCODE is a database of all kinds of noncoding RNAs (except tRNAs and rRNAs)
98. Novoseek: Novoseek extracts knowledge from biological databases and text repositories, enabling users to uncover the knowledge hidden within these data sources
99. Novus Biologicals: Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guaranteed
100. Nuclear Receptor Signaling Atlas: The mission of NURSA is to accrue, develop, and communicate information that advances our understanding of the roles of nuclear receptors (NRs) in human diseases and conditions in which NRs play an integral role.
101. OCA: OCA a browser-database for protein structure/function
102. Online Mendelian Inheritance in Man: OMIM (Online Mendelian Inheritance in Man): a catalog of human genes and genetic disorders with a lot of information about many different aspects (medical and genetic).GeneCards presents a list of diseases listed as allelic variants in the respective entry for the gene, synonyms for the gene, and a link to the OMIM database entry
103. OriGene : OriGene is a world-wide supplier of authentic full-length CDNA clones in a standard expression vector
104. Orphanet: Orphanet is the reference portal for information on rare diseases and orphan drugs, for all audiences. Orphanet's aim is to help improve the diagnosis, care and treatment of patients with rare diseases.
105. PathCards: PathCards is an integrated database of human pathways and their annotations. Human pathways were clustered into SuperPaths based on gene content similarity. Each PathCards provides information on one SuperPath which represent one or more human pathways. 1073 SuperPath entries, consolidated from 12 sources
106. PaxDb: Protein Abundance Across Organisms: PaxDb is a database of protein abundances across organisms
107. Pharmacogenomics Knowledge Base: The PharmGKB is an integrated resource about how variation in human genes leads to variation in our response to drugs
108. PhosphoSitePlus: PhosphoSitePlus from CST is a curated, sequence-oriented protein database dedicated to in vivo phosphorylation sites
109. ProSci Inc: With over 18,000 completed Custom Antibody projects and 18 years of experience, ProSci specializes in custom polyclonal, monoclonal, and single domain antibody development and production using its own USDA and NIH accredited animal facilities.
110. ProSpec: ProSpec, a biotechnology company, specializes in production of bacterial-derived recombinant proteins
111. ProteoGenix: ProteoGenix is a leading life sciences organization which provides services in molecular biology, protein engineering and immunology, including recombinant proteins, custom peptides, antibodies, and custom gene synthesis,subcloning and mutagenesis.
112. ProteomicsDB: ProteomicsDB is dedicated to expedite the identification of the human proteome and its use across the scientific community.
113. Proteopedia: Proteopedia is a project that provides structural and functional knowledge about protein, RNA, DNA, and other macromolecules, and their assemblies and interactions with small molecules, in a manner that is relevant and broadly accessible to students and scientists
114. ProtoNet: ProtoNet at the Hebrew University of Jerusalem provides global classification of the proteins into hierarchical clusters
115. Pseudogene.org: Pseudogene.org, a project of the Gerstein Lab at Yale University, provides information on pseudogenes and intergenic analyses
116. Qiagen: Qiagen provides sample and assay technologies
117. R&D Systems: R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry
118. Reactome, a curated pathway database: Reactome is an open-source, open access, manually curated and peer-reviewed pathway database
119. Residual Variation Intolerance Score: RVIS (Residual Variation Intolerance Score) is a gene-based score intended to help in the interpretation of human sequence data. The intolerance score in its current form is based upon allele frequency data as represented in whole exome sequence data from the NHLBI-ESP6500 data set.
120. RNA Database: RNAdb (RNA Database) is a database for RNA genes annotations
121. Saccharomyces Genome Database: (Saccharomyces Genome Database) is a scientific database of the molecularbiology and genetics of the yeast Saccharomyces cerevisiae, which is commonly known as baker's or budding yeast
122. Santa Cruz Biotechnology, (SCBT): Santa Cruz Biotechnology, SCBT, is a leading producer of antibodies, RNAi, CRISPR KO/Activation products, biochemicals and labware for research applications.
123. SIGnaling Network Open Resource: SIGNOR, the SIGnaling Network Open Resource, organizes and stores signaling information published in the scientific literature in a structured format.
124. SIMAP: SIMAP is a database containing the similarity space formed by all amino-acid sequences from public databases and completely sequenced genomes
125. Sino Biological: Sino Biological offers cost-effective premium quality services and reagents for life science research and biological product development
126. SNP Database: SNP Database at NCBI provides information on Single Nucleotide Polymorphisms
127. SNPedia: SNPedia is a wiki investigating human genetics. It shares information about the effects of variations in DNA, citing peer-reviewed scientific publications.
128. SOURCE: SOURCE (The Stanford Online Universal Resource for Clones and ESTs) compiles information from several publicly accessible databases, including UniGene, dbEST, UniprotKB/Swiss-Prot, GeneMap99, GeneCardsandEntrezGene
129. SPIRE: Systematic Protein Investigative Research Environment, proteomics analysis pipeline (frozen)
130. St John's Laboratory: St John’s laboratory was founded upon the mission to improve quality, reproducibility, and reliability through antibody validation.
131. STRING: STRING is a database of known and predicted protein-protein interactions
132. SwitchGear Genomics: SwitchGear Genomics identifies functional elements in the human genome and develops this genomic content into novel high-throughput cell-based functional assays
133. Taconic Biosciences: Taconic Biosciences aims to create a difference in human health by providing the best, most relevant mouse and rat models to researchers in the life science community.
134. The Alternative Splicing Database: The Alternative Splicing Database (ASD) maintains a database of alternative splice events and the resultant isoform splice patterns of genes from human, and other model species
135. The Drug Gene Interaction Database: The Drug-Gene Interaction Database is a web resource that consolidates disparate data sources describing drug-gene interactions and gene druggability
136. The Genotype-Tissue Expression project: The Genotype-Tissue Expression project (GTEx) is providing a comprehensive atlas of gene expression and regulation across multiple human tissues.
137. The Human Phenotype Ontology: The Human Phenotype Ontology (HPO) aims to provide a standardized vocabulary of phenotypic abnormalities encountered in human disease.
138. The MaxQuant DataBase: MaxQB is a database that stores and displays collections of large proteomics projects and allows joint analysis and comparison
139. The University of Copenhagen DISEASES: The University of Copenhagen DISEASES database provides disease-gene associations mined from literature
140. TISSUES: TISSUES is a frequently updated web resource that integrates evidence on tissue expression from manually curated literature, proteomics and transcriptomics screens, and automatic text mining.
141. Tocris Bioscience: Tocris Bioscience is the leading supplier of high performance tools for life science research. The Tocris range of small molecules and peptides includes novel and exclusive receptor ligands, ion channel modulators, enzyme inhibitors, caged compounds, fluorescent probes, and screening libraries
142. TreeFam: TreeFam contains gene phylogenetic trees
143. Tumor Gene Family of Databases: The Tumor Gene Database (TGDB) contains information about genes that are targets for cancer-causing mutations
144. UCSC Golden Path: UCSC Golden Path: the University of California at Santa Cruz Human Draft Genomic Assembly
145. Undiagnosed Diseases Network: The Undiagnosed Diseases Network (UDN) is a research study that is funded by the National Institutes of Health Common Fund. Its purpose is to bring together clinical and research experts from across the United States to solve the most challenging medical mysteries using advanced technologies.
146. Unified Medical Language System: The UMLS integrates and distributes key terminology, classification and coding standards, and associated resources to promote creation of more effective and interoperable biomedical information systems and services, including electronic health records.
147. UniGene: UniGene: an experimental system for automatically partitioning GenBank sequences into a non-redundant set of gene-oriented clusters. GeneCards extracts from UniGene the cluster (Hs.) number, gene symbol or title, GenBank accession, EST's clone identifier and library ID
148. UniProtKB/Swiss-Prot: UniprotKB/Swiss-Prot stores information about proteins (the sequence, some notes about cellular functions, and many other useful data, as well as links to related sites on the web). GeneCards extracts from Swiss-Prot the name of the product(s) of the gene and data about the cellular functions, similarities, involvement in diseases, and links to other databases related to the gene product(s)
149. UniProtKB/TrEMBL: UniprotKB/TrEMBL: a computer-annotated supplement of Swiss-Prot that contains all the translations of EMBL nucleotide sequence entries not yet integrated in Swiss-Prot. GeneCards extracts from TrEMBL the name of the product(s) of the gene and data about the cellular functions, similarities, involvement in diseases, and links to other databases related to the gene product(s)
150. USFDA Approved Drugs: The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, animal foods & feed and veterinary products.
151. Vector BioLabs : Vector BioLabs provides gene delivery products & services using many viral platforms, including recombinant adenoviruses, adeno-associated virus (AAV) and lentivirus
152. VectorBuilder: The VectorBuilder platform, powered by Cyagen, allows researchers to custom design and order their own vectors online.
153. ViGene Biosciences Inc: ViGene Biosciences Inc is a genomics tool company that develops cutting-edge, next generation life science research reagents to support high throughput drug discovery and functional genomics.
154. VISTA Enhancer Browser: A resource for experimentally validated human and mouse noncoding fragments with gene enhancer activity as assessed in transgenic mice.
155. WormBase: WormBase, the genome and biology of C.elegans
156. CNVD - CNVD (Copy Number Variation in Disease) is a systematic and comprehensive database for copy number variations and related diseases, in which all the records were manually extracted from experimental data published in CNV-related articles. Hence, CNVD database is a reliable and comprehensive resource for studying diseases associated copy number variations.
157. Cochrane Library - The Cochrane Library (ISSN 1465-1858) is a collection of six databases that contain different types of high-quality, independent evidence to inform healthcare decision-making, and a seventh database that provides information about Cochrane groups. Cochrane's mission is to promote evidence-informed health decision-making by producing high-quality, relevant, accessible systematic reviews and other synthesized research evidence.
158. Cosmic - Catalogue of somatic mutations in cancer.
159. dbSNP - The Single Nucleotide Polymorphism Database (dbSNP) is a free public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the National Human Genome Research Institute (NHGRI).
160. DGIdb - The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development.
161. ExPASy - ExPASy is the SIB Bioinformatics Resource Portal which provides access to scientific databases and software tools (i.e., resources) in different areas of life sciences including proteomics, genomics, phylogeny, systems biology, population genetics, transcriptomics etc.
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