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  COGPipeline -COG分析软件

“COG”是Cluster of Orthologous Groups of proteins.构成每个COG的蛋白都是被假定为来自于一个祖先蛋白,并且因此或者是orthologs或者是paralogs。Orthologs是指来自于不同物种的由垂直家系(物种形成)进化而来的蛋白,并且典型的保留与原始蛋白有相同的功能。Paralogs是那些在一定物种中的来源于基因复制的蛋白,可能会进化出新的与原来有关的功能。

 

COG分类

 

  • INFORMATION STORAGE AND PROCESSING
    • [J] Translation, ribosomal structure and biogenesis
    • [A] RNA processing and modification
    • [K] Transcription
    • [L] Replication, recombination and repair
    • [B] Chromatin structure and dynamics
  • CELLULAR PROCESSES AND SIGNALING
    • [D] Cell cycle control, cell division, chromosome partitioning
    • [Y] Nuclear structure
    • [V] Defense mechanisms
    • [T] Signal transduction mechanisms
    • [M] Cell wall/membrane/envelope biogenesis
    • [N] Cell motility
    • [Z] Cytoskeleton
    • [W] Extracellular structures
    • [U] Intracellular trafficking, secretion, and vesicular transport
    • [O] Posttranslational modification, protein turnover, chaperones
  • METABOLISM
    • [C] Energy production and conversion
    • [G] Carbohydrate transport and metabolism
    • [E] Amino acid transport and metabolism
    • [F] Nucleotide transport and metabolism
    • [H] Coenzyme transport and metabolism
    • [I] Lipid transport and metabolism
    • [P] Inorganic ion transport and metabolism
    • [Q] Secondary metabolites biosynthesis, transport and catabolism
  • POORLY CHARACTERIZED
    • [R] General function prediction only
    • [S] Function unknown

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我们开发了一套程序名为COGPipeline, 可以调动NCBI blast+将核酸序列和蛋白序列对COG库进行序列相似性比较,提取COG注释,并调用R进行统计绘图。

COGPipeline [PPT]

COG分析结果:示例

 

 
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